| First Author | West JD | Year | 1987 |
| Journal | Biochem Genet | Volume | 25 |
| Issue | 7-8 | Pages | 543-61 |
| PubMed ID | 3447589 | Mgi Jnum | J:9137 |
| Mgi Id | MGI:57600 | Doi | 10.1007/BF00554356 |
| Citation | West JD, et al. (1987) High activity of an unstable form of glucose phosphate isomerase in the mouse. Biochem Genet 25(7-8):543-61 |
| abstractText | Quantitative electrophoretic studies of the three allozymes of glucose phosphate isomerase (GPI-1) produced by Gpi-1sa/Gpi-1sc heterozygous mice revealed two opposing influences on GPI-1 activity. First, the GPI-1AC heterodimer is less stable than GPI-1AA but more stable than the GPI-1CC homodimer. Second, a genetic determinant that maps close to or within the Gpi-1s structural gene causes elevated activity of GPI-1AC and probably also GPI-1CC dimers. The relative lability of these allozymes masks this elevated activity in some tissues but the effect is probably ubiquitous. The significance of these observations is discussed. |
