| First Author | Soloski MJ | Year | 1988 |
| Journal | Proc Natl Acad Sci U S A | Volume | 85 |
| Issue | 9 | Pages | 3100-4 |
| PubMed ID | 3362864 | Mgi Jnum | J:23664 |
| Mgi Id | MGI:71539 | Doi | 10.1073/pnas.85.9.3100 |
| Citation | Soloski MJ, et al. (1988) Qa-region class I gene expression: identification of a second class I gene, Q9, encoding a Qa-2 polypeptide. Proc Natl Acad Sci U S A 85(9):3100-4 |
| abstractText | A feature of the expression of the tissue-specific class I antigen Qa-2 is the quantitative variation among mouse strains. Recently, the class I gene Q7 has been shown to encode a protein product that is biochemically indistinguishable from the lymphocyte-bound Qa-2 molecule. Utilizing gene transfection, we have identified a second Qa-2 subregion class I gene (Q9), in H-2b mice, which encodes a polypeptide biochemically similar to the Q7 and the Qa-2 polypeptides. Furthermore, we have observed that cell lines transfected with the allelic forms of the Q7 gene from C57BL/10 (Qa-2hi) or BALB/C (Qa-2low) display quantitative differences in cell-surface expression. Based on these studies, we suggest that gene dosage and allele-specific variation in cell-surface expression contribute to the strain-specific variation in the levels of Qa-2 antigen expression. |
