| First Author | Potter M | Year | 1988 |
| Journal | Genomics | Volume | 2 |
| Issue | 3 | Pages | 257-62 |
| PubMed ID | 3165083 | Mgi Jnum | J:9261 |
| Mgi Id | MGI:57724 | Doi | 10.1016/0888-7543(88)90010-9 |
| Citation | Potter M, et al. (1988) Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage. Genomics 2(3):257-62 |
| abstractText | Early-passage skin fibroblasts from different inbred and congenic strains of mice were X-irradiated (1 Gy), and the number of chromatid breaks was determined at 2.0 h after irradiation. The cells from DBA/2N, C3H/HeN, STS/A, C57BL/6N, BALB/cJ, and AKR/N had 25 to 42 chromatid breaks per 100 metaphase cells (efficient repair phenotype). NZB/NJ had greater than 78 and BALB/cAn had 87 to 110 chromatid breaks per 100 cells (inefficient repair phenotype). Differences between BALB/cAn and BALB/c. DBA/2 congenic strains which carry less than 1% of the DBA/2 genome indicate that two genes, one on chromosome 1 linked to bcl-2-Pep-3 and the other on chromosome 4 closely linked to Fv-1, affect the efficiency with which the cells repair radiation-induced chromatin damage. |
