| First Author | Giometti CS | Year | 1988 |
| Journal | J Biol Chem | Volume | 263 |
| Issue | 30 | Pages | 15781-4 |
| PubMed ID | 3170611 | Mgi Jnum | J:15482 |
| Mgi Id | MGI:63602 | Doi | 10.1016/s0021-9258(19)37656-2 |
| Citation | Giometti CS, et al. (1988) A heritable variant of mouse liver ornithine aminotransferase (EC 2.6.1.13) induced by ethylnitrosourea. J Biol Chem 263(30):15781-4 |
| abstractText | A variant of ornithine aminotransferase (OAT, EC 2.6.1.13) has been detected in an offspring of a male mouse treated with ethylnitrosourea. The evidence presented to support the identification of the protein variant (ENU 2) as altered OAT includes (a) a corresponding 50% decrease in the abundance of a protein, located one charge unit basic to the variant, which comigrates on two-dimensional gel patterns with purified mouse liver OAT; (b) the binding of anti-rat-OAT antibody to the variant; (c) the increased abundance of the variant protein in the livers of mice fed a high protein diet (85% casein); and (d) purification of the variant through an OAT purification protocol. |
