| First Author | Gaunt SJ | Year | 1988 |
| Journal | Development | Volume | 103 |
| Issue | 1 | Pages | 135-44 |
| PubMed ID | 2904354 | Mgi Jnum | J:32272 |
| Mgi Id | MGI:79773 | Doi | 10.1242/dev.103.1.135 |
| Citation | Gaunt SJ (1988) Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5. Development 103(1):135-44 |
| abstractText | By use of in situ hybridization experiments, the mouse homeobox genes Hox-3.1 and Hox-1.5 are compared in the temporal and spatial patterns of their embryonic transcripts. Transcripts of both genes are first detected at about 7 1/2 days, although the appearance of Hox-3.1 transcripts apparently follows Hox-1.5 after a small delay. Hox-3.1 and Hox-1.5 transcripts occupy domains which are different, although overlapping, along the anteroposterior axis of the embryo. The domains are first established within the ectoderm and mesoderm germ layers at 7 1/2-8 days, but subsequently they persist within the nervous system, the prevertebral column and within at least some of the organs (the thyroid, lung, stomach, mesonephric and metanephric kidneys) at 12 1/2 days. In discussion, two different mechanisms are considered by which positional information might first be generated within the germ layers. |
