| First Author | Mardon G | Year | 1989 |
| Journal | Science | Volume | 243 |
| Issue | 4887 | Pages | 78-80 |
| PubMed ID | 2563173 | Mgi Jnum | J:9550 |
| Mgi Id | MGI:58010 | Doi | 10.1126/science.2563173 |
| Citation | Mardon G, et al. (1989) Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome. Science 243(4887):78-80 |
| abstractText | The ZFY gene in the sex-determining region of the human Y chromosome encodes a zinc-finger protein that may be the testis-determining factor, TDF. Although the Y chromosomes of most placental mammals carry a single homolog of ZFY, the mouse Y chromosome has two homologs, both in the sex-determining (Sxr) region. Zfy-1 alone may suffice to determine maleness; Zfy-2 is dispensable, as it was deleted in an Sxr variant that retains sex-determining function but has lost other genes. Both loci mapped near the centromere of the mouse Y chromosome. The Y chromosomes of the subspecies Mus musculus musculus and M. m. domesticus were distinguishable by a Zfy-1 restriction fragment polymorphism, which can be used to study their differing interactions with autosomal sex-determining genes. |
