| First Author | Nagamine CM | Year | 1989 |
| Journal | Science | Volume | 243 |
| Issue | 4887 | Pages | 80-3 |
| PubMed ID | 2563174 | Mgi Jnum | J:9551 |
| Mgi Id | MGI:58011 | Doi | 10.1126/science.2563174 |
| Citation | Nagamine CM, et al. (1989) Chromosome mapping and expression of a putative testis-determining gene in mouse. Science 243(4887):80-3 |
| abstractText | Isolation and mapping of a mouse complementary DNA sequence (mouse Y-finger) encoding a multiple, potential zinc-binding, finger protein homologous to the candidate human testis-determining factor gene is reported. Four similar sequences were identified in Hind III-digested mouse genomic DNA. Two (7.2 and 2.0 kb) were mapped to the Y chromosome. Only the 2.0-kb fragment, however, was correlated with testis determination. Polymerase chain reaction analysis suggests both Y loci are transcribed in adult testes. A 3.6-kb fragment was mapped to the X chromosome between the T16H and T6R1 translocation breakpoints, and a fourth (6.0 kb) was mapped to chromosome 10. Hence, mYfin sequences have been duplicated several times in the mouse, although they are not duplicated in humans. |
