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Publication : KIN, a mammalian nuclear protein immunologically related to E. coli RecA protein.

First Author  Angulo JF Year  1989
Journal  Mutat Res Volume  217
Issue  2 Pages  123-34
PubMed ID  2493134 Mgi Jnum  J:15800
Mgi Id  MGI:63911 Doi  10.1016/0921-8777(89)90064-5
Citation  Angulo JF, et al. (1989) KIN, a mammalian nuclear protein immunologically related to E. coli RecA protein. Mutat Res 217(2):123-34
abstractText  A polypeptide of about 120 kDa, called KIN, has been identified in rat FR 3T3 cells by immunoblotting using affinity-purified antibodies against the RecA protein of Escherichia coli (38 kDa). The KIN protein as shown by fluorescent light microscopy and electron microscopy is essentially concentrated in the nucleus. Its level is higher in proliferating than in quiescent cells. Cell treatment with mitomycin C increases the level of the KIN protein. We sought similar proteins in other mammalian cells. Proteins with the same electrophoretic mobility were detected in mouse, monkey and human cell lines as well as in rat and mouse embryos.
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