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Publication : Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.

First Author  Lan NC Year  1989
Journal  Genomics Volume  4
Issue  4 Pages  552-9
PubMed ID  2744764 Mgi Jnum  J:9880
Mgi Id  MGI:58337 Doi  10.1016/0888-7543(89)90279-6
Citation  Lan NC, et al. (1989) Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease. Genomics 4(4):552-9
abstractText  Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).
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