| First Author | Stone JC | Year | 1989 |
| Journal | Genomics | Volume | 5 |
| Issue | 1 | Pages | 70-5 |
| PubMed ID | 2570031 | Mgi Jnum | J:9968 |
| Mgi Id | MGI:58425 | Doi | 10.1016/0888-7543(89)90088-8 |
| Citation | Stone JC, et al. (1989) The murine retinoblastoma homolog maps to chromosome 14 near Es-10. Genomics 5(1):70-5 |
| abstractText | Restriction fragment length variants have been exploited to map genetically Rb-1, the murine homolog of the human retinoblastoma gene. Rb-1 localized to mouse chromosome 14 on the basis of results from analysis of somatic cell hybrids. In an interspecific backcross involving Mus spretus, Rb-1 and the murine homolog of the human esterase D gene (ESD), which we refer to here as Esd, were inseparable. Furthermore, the strain distribution patterns of Rb-1 and Es-10 are the same in 31 of 32 recombinant inbred strains. Close linkage of the chromosome 14 morphological marker hairless (hr) to Rb-1 is also implied. These results localize Rb-1 on the mouse linkage map and provide close genetic markers to follow Rb-1 in somatic as well as in germline genetic experiments. Additionally, the results suggest that Es-10 is the murine homolog of ESD and provide further evidence for linkage conservation during mammalian evolution. |
