| First Author | Wahlström A | Year | 1989 |
| Journal | Pain | Volume | 38 |
| Issue | 1 | Pages | 71-5 |
| PubMed ID | 2506504 | Mgi Jnum | J:25800 |
| Mgi Id | MGI:73524 | Doi | 10.1016/0304-3959(89)90075-4 |
| Citation | Wahlstrom A, et al. (1989) The sensitivity to noxious heat in relation to brain and liver opioid glucuronidation in inbred strains of mice. Pain 38(1):71-5 |
| abstractText | The glucuronidation of morphine and naloxone was demonstrated in the brain and liver in 2 inbred strains of mice, C57BL/6J (B6) and DBA/2J (D2) and their F1 hybrid generation. These strains showed a significant difference in latency of withdrawal in the tail-immersion test, the B6 strain being the most sensitive. The rate of naloxone glucuronidation in the brain was 5 times higher in the B6 than in the D2 strain. In the liver the UDP-glucuronosyl transferase (UDPGT) activity was slightly higher in the D2 strain. The naloxone- and morphine-3'-glucuronide (N3G, M3G) formation rate ratio was close to 1 in both the brain and liver in all except the B6 strain, where it was 2.6 in the brain. There was a correlation between formation rate of M3G and N3G (r = 0.65 brain and r = 0.73 liver). Our results indicate a common glucuronidation pathway for morphine and naloxone. |
