First Author | Kim Y | Year | 1989 |
Journal | Proc Natl Acad Sci U S A | Volume | 86 |
Issue | 20 | Pages | 7716-20 |
PubMed ID | 2573058 | Mgi Jnum | J:31895 |
Mgi Id | MGI:79404 | Doi | 10.1073/pnas.86.20.7716 |
Citation | Kim Y, et al. (1989) Drosophila NK-homeobox genes. Proc Natl Acad Sci U S A 86(20):7716-20 |
abstractText | Four Drosophila melanogaster homeobox genes were found by screening a genomic DNA library with oligodeoxynucleotides that correspond to a conserved amino acid sequence that is part of the putative of homeobox proteins that recognizes nucleotide sequences in DNA. The amino acid sequences of NK-2, NK-3, and NK-4 homeoboxes are more closely related to one another (59-66% homology) than they are to other Drosophila homeoboxes (28-54% homology), whereas the homeobox of NK-1 is most closely related, in order of decreasing homology, to muscle segment homeobox, zerknullt-1, NK-3, and distal-less homeoboxes. Three of the genes, NK-1, NK-3, and NK-4, comprise a cluster of homeobox genes located in the 93E1-5 region of the right arm of the third chromosome, whereas the fourth homeobox gene, NK-2, is located in the 1C1-5 region of the X chromosome. |