| First Author | Nadeau JH | Year | 1989 |
| Journal | Genomics | Volume | 5 |
| Issue | 3 | Pages | 454-62 |
| PubMed ID | 2482246 | Mgi Jnum | J:10240 |
| Mgi Id | MGI:58694 | Doi | 10.1016/0888-7543(89)90009-8 |
| Citation | Nadeau JH, et al. (1989) A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11. Genomics 5(3):454-62 |
| abstractText | Type I and type II keratins are major constituents of intermediate filaments that play a fundamental role in the cytoskeletal network. By using both somatic cell hybrids and conventional and interspecific linkage crosses, several genes encoding type I keratins, including the epidermal keratin K10, were shown to be closely linked to the homeobox-2 complex and the rex locus on mouse chromosome 11. The absence of crossovers between type I keratin-encoding genes and rex (N = 239), a locus affecting hair development, raises the possibility that mutations at rex and neighboring loci affecting skin and hair development involve type I keratin genes. |
