| First Author | Chen Q | Year | 1990 |
| Journal | EMBO J | Volume | 9 |
| Issue | 2 | Pages | 415-24 |
| PubMed ID | 2303035 | Mgi Jnum | J:29009 |
| Mgi Id | MGI:76638 | Doi | 10.1002/j.1460-2075.1990.tb08126.x |
| Citation | Chen Q, et al. (1990) The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J 9(2):415-24 |
| abstractText | We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes. |
