| First Author | Sironi M | Year | 1990 |
| Journal | Toxicology | Volume | 60 |
| Issue | 3 | Pages | 263-73 |
| PubMed ID | 2315945 | Mgi Jnum | J:27955 |
| Mgi Id | MGI:75589 | Doi | 10.1016/0300-483x(90)90149-b |
| Citation | Sironi M, et al. (1990) 3-Methylcholanthrene induces differential inhibition of humoral and cell mediated immune responses in mice of different ages. Toxicology 60(3):263-73 |
| abstractText | C57B1/6 mice aged 2-3 and 13-14 months were treated i.p. with 3-methylcholanthrene. A single dose of 25 mg/kg reduced primary antibody production to the T-dependent antigen sheep red blood cells by 20% in mice aged 2-3 months and by 90% in 13-14-month-old animals. The same treatment did not reduce antibody production to the T-independent antigen pneumococcal polysaccharide type III in young mice, but reduced this response by 50% in 13-14-month-old animals. Blastogenesis to concanavalin A, phytohemagglutinin and alloantigens, that is mediated by T lymphocytes, was consistently reduced in young animals but only marginally affected, when at all, in 13-14-month-old mice. Blastogenesis to lipopolysaccharide, mediated by B lymphocytes, was reduced in mice of both ages, though in older mice it was affected later than in younger animals. Addition of 3-methylcholanthrene in vitro increased T lymphocyte responses equally in mice of both ages and did not modify B lymphocyte proliferation. Results presented here show that older mice are not necessarily more susceptible to all types of immunosuppression induced by a xenobiotic like 3-methylcholanthrene and that the sensitivity of the different facets of the immune response can change with aging. |
