| First Author | Saito N | Year | 1985 |
| Journal | Exp Clin Immunogenet | Volume | 2 |
| Issue | 1 | Pages | 24-35 |
| PubMed ID | 2978828 | Mgi Jnum | J:26258 |
| Mgi Id | MGI:75375 | Citation | Saito N, et al. (1985) Low responsiveness to MLM bacilli associated with an impaired macrophage function in CBA/J mice. Exp Clin Immunogenet 2(1):24-35 |
| abstractText | It has previously been reported that susceptibility to Mycobacterium lepraemurium (MLM) infection (subcutaneous inoculation) differs markedly between CBA/J and C57BL/6 mice. The high susceptibility of CBA/J mice was shown to be due to the generation of cyclophosphamide-sensitive, I-Jk-positive suppressor T cells. In the present study, we attempt to show functional differences between splenic macrophages of both strains of mice in terms of their phagocytic and antigen-presenting activities against MLM bacilli. The results show that (a) the secondary MLM-induced T-cell proliferative response is dependent on Ia-positive antigen-presenting cells (APC), (b) macrophages of CBA/J mice are able to present antigens to F1 T cells, and yet (c) they show an extremely low phagocytic activity, (d) antigen presentation by APC of CBA/J mice lasted for a longer period than that of C57BL/6 mice after MLM infection. These results suggest that there is a functional difference in CBA/J and C57BL/6 APC, which could account for the phenotypic difference in immune responsiveness to MLM bacilli. |
