| First Author | Mohl VK | Year | 1990 |
| Journal | Genetics | Volume | 124 |
| Issue | 4 | Pages | 949-55 |
| PubMed ID | 2323557 | Mgi Jnum | J:25866 |
| Mgi Id | MGI:73575 | Doi | 10.1093/genetics/124.4.949 |
| Citation | Mohl VK, et al. (1990) Genetic differences in the duration of the lymphocyte heat shock response in mice. Genetics 124(4):949-55 |
| abstractText | Lymphocytes from adult mice bearing a known difference in genetic susceptibility to teratogen-induced exencephaly (SWV/SD, and DBA/2J) were evaluated for changes in protein synthesis following an in vivo heat treatment. Particular attention was paid to changes indicative of the heat shock response, a highly conserved response to environmental insult consisting of induction of a few, highly conserved proteins with simultaneous decreases in normal protein synthesis. The duration of heat shock protein induction in lymphocytes was found to be increased by 1 hr in the teratogen-sensitive SWV/SD strain as compared to the resistant DBA/2J strain. Densitometric analysis revealed a significant decrease in the relative synthesis of at least two non-heat shock proteins (36 kD and 45 kD) in the SWV/SD lymphocytes as compared to DBA/2J cells. The increased sensitivity of protein synthesis to hyperthermia in the SWV/SD lymphocytes were lost in the F1 progeny of reciprocal crosses between SWV/SD and DBA/2J mouse strains. Sensitivity to hyperthermia-induced exencephaly is recessive to resistance in these crosses. The relationship between altered protein synthesis and teratogen susceptibility is discussed. |
