| First Author | Siracusa LD | Year | 1990 |
| Journal | Genomics | Volume | 6 |
| Issue | 3 | Pages | 491-504 |
| PubMed ID | 1970329 | Mgi Jnum | J:10439 |
| Mgi Id | MGI:58890 | Doi | 10.1016/0888-7543(90)90479-e |
| Citation | Siracusa LD, et al. (1990) A molecular genetic linkage map of mouse chromosome 2. Genomics 6(3):491-504 |
| abstractText | Interspecific backcross mice were used to create a molecular genetic linkage map of chromosome 2. Genomic DNAs from N2 progeny were subjected to Southern blot analysis using molecular probes that identified the Abl, Acra, Ass, C5, Cas-1, Fshb, Gcg, Hox-5.1, Jgf-1, Kras-3, Ltk, Pax-1, Prn-p, and Spna-2 loci; these loci were added to the 11 loci previously mapped to the distal region of chromosome 2 in the same interspecific backcross to generate a composite multilocus linkage map. Several loci mapped near, and may be the same as, known mutations. Comparisons between the mouse and the human genomes indicate that mouse chromosome 2 contains regions homologous to at least six human chromosomes. Mouse models for human diseases are discussed. |
