| First Author | Panthier JJ | Year | 1990 |
| Journal | Genetics | Volume | 125 |
| Issue | 1 | Pages | 175-82 |
| PubMed ID | 2341029 | Mgi Jnum | J:31201 |
| Mgi Id | MGI:78700 | Doi | 10.1093/genetics/125.1.175 |
| Citation | Panthier JJ, et al. (1990) Evidence for mitotic recombination in Wei/+ heterozygous mice. Genetics 125(1):175-82 |
| abstractText | A number of alleles at coat color loci of the house mouse give rise to areas of wild-type pigmentation on the coats of otherwise mutant animals. Such unstable alleles include both recessive and dominant mutations. Among the latter are several alleles at the W locus. In this report, phenotypic reversions of the Wei allele at the W locus were studied Mice heterozygous in repulsion for both Wei and buff (bf) [i.e. Wei+/+bf] were examined for the occurrence of phenotypic reversion events. Buff (bf) is a recessive mutation, which lies 21 cM from W on the telomeric side of chromosome 5 and is responsible for the khaki colored coat of nonagouti buff homozygotes (a/a; bf/bf). Two kinds of fully pigmented reversion spots were recovered on the coats of a/a; Wei+/+bf mice: either solid black or khaki colored. Furthermore phenotypic reversions of Wei/+ were enhanced significantly following X-irradiation of 9.25-day-old Wei/+ embryos (P less than 0.04). These observations are consistent with the suggestion of a role for mitotic recombination in the origin of these phenotypic reversions. In addition these results rise the intriguing possibility that some W mutations may enhance mitotic recombination in the house mouse. |
