| First Author | Ozkaynak E | Year | 1990 |
| Journal | EMBO J | Volume | 9 |
| Issue | 7 | Pages | 2085-93 |
| PubMed ID | 2357959 | Mgi Jnum | J:19592 |
| Mgi Id | MGI:67758 | Doi | 10.1002/j.1460-2075.1990.tb07376.x |
| Citation | Ozkaynak E, et al. (1990) OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. EMBO J 9(7):2085-93 |
| abstractText | Amino acid sequences of two tryptic peptides derived from enriched bovine osteogenic protein preparations revealed considerable homology to two members of the TGF-beta (transforming growth factor beta) supergene family, DPP (decapentaplegic protein) of Drosophila and Vg-1 (vegetal protein) of Xenopus. Building upon this information we constructed a synthetic consensus gene to use as a probe to screen human genomic libraries. This resulted in the isolation of three interrelated genes. Among these were BMP-2b and BMP-3 which have recently been described by others. The third gene, termed OP-1 (osteogenic protein one), is new and was subsequently shown to encode the human homolog of a major component of bovine osteogenic protein. The genomic clones were used to isolate the corresponding complementary DNA (cDNA) clones. Sequence analysis indicates that OP-1 is a relative of the murine Vgr-1 (Vg-1 related gene). This report describes the cDNA structure and putative amino acid sequence of OP-1. |
