| First Author | Shefner R | Year | 1990 |
| Journal | J Immunol | Volume | 145 |
| Issue | 5 | Pages | 1609-14 |
| PubMed ID | 1974568 | Mgi Jnum | J:10673 |
| Mgi Id | MGI:59120 | Doi | 10.4049/jimmunol.145.5.1609 |
| Citation | Shefner R, et al. (1990) Identification of a new V kappa gene family that is highly expressed in hybridomas from an autoimmune mouse strain [see comments]. J Immunol 145(5):1609-14 |
| abstractText | We have identified a new murine V kappa family that contains five to seven members, one member of which encodes the L chain V region of an anti-dsDNA antibody produced by a BALB/c hybridoma, C8.5. The cloned C8.5 V kappa gene exhibits highest homology with a human V kappa gene that was cloned from a nonproductive rearrangement but has never been seen in an expressed repertoire. Because this family was first identified in an autoantibody, we studied its expression in an autoimmune mouse strain. This V kappa family is expressed in 20% of hybridomas from NZB mice. |
