| First Author | Smidt M | Year | 1990 |
| Journal | J Clin Invest | Volume | 86 |
| Issue | 4 | Pages | 1151-7 |
| PubMed ID | 2212004 | Mgi Jnum | J:48350 |
| Mgi Id | MGI:1267239 | Doi | 10.1172/JCI114820 |
| Citation | Smidt M, et al. (1990) Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas. J Clin Invest 86(4):1151-7 |
| abstractText | An abnormality in the c-sis protooncogene was identified in leukocyte DNA from members of a family predisposed to the development of meningioma, and was found to be associated with the development of the tumor in those individuals. Molecular analysis of this abnormality demonstrated a deletion within the fifth intron of the c-sis gene. The normal c-sis gene has an Alu sequence in this region which includes two perfect 130 nucleotide repeated sequences separated by 5 bp. The deleted c-sis allele is missing precisely one copy of the 130 bp repeat and the intervening 5 bp. An identical deletion was also found in DNA from 1 of 13 sporadic meningiomas. |
