| First Author | Fortier AH | Year | 1990 |
| Journal | Infect Immun | Volume | 58 |
| Issue | 12 | Pages | 4149-52 |
| PubMed ID | 2254035 | Mgi Jnum | J:25792 |
| Mgi Id | MGI:73516 | Doi | 10.1128/iai.58.12.4149-4152.1990 |
| Citation | Fortier AH, et al. (1990) Susceptibility of inbred mice to Leishmania major infection: genetic analysis of macrophage activation and innate resistance to disease in individual progeny of P/J (susceptible) and C3H/HeN (resistant) mice. Infect Immun 58(12):4149-52 |
| abstractText | We tested the possibility that two phenotypic traits, defective activation of macrophage antileishmanial activities and susceptibility to infection with Leishmania major, were controlled by the same gene. We used P/J (susceptible) and C3H/HeN (resistant) mice to breed F1, backcross (Bx), and F2 mice that were tested individually for both traits, each of which is known to be controlled by a single autosomal gene. We found no correlation between the macrophage defect and cutaneous disease. There was a correlation between development of systemic disease and defective macrophage activation in Bx mice; this correlation, however, was not confirmed in the F2 population. |
