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Publication : The cutaneous microbiology of haired and hairless mice.

First Author  Harnby D Year  1990
Journal  J Appl Bacteriol Volume  69
Issue  5 Pages  686-91
PubMed ID  2276985 Mgi Jnum  J:25808
Mgi Id  MGI:73532 Doi  10.1111/j.1365-2672.1990.tb01563.x
Citation  Harnby D, et al. (1990) The cutaneous microbiology of haired and hairless mice. J Appl Bacteriol 69(5):686-91
abstractText  The cutaneous microflora of the mid-dorsal area of hairless and haired mice was studied by processing skin biopsies. In both C3H and CBA hairless genotype animals the prevalence of colonization and the bacterial density were significantly greater than in the haired animals. The dominant bacteria were staphylococci and aerobic coryneforms. No propionibacteria were isolated. Temporal studies with C3H mice showed that from 0 to 9 days after birth the cutaneous microflora reduced and from then on the haired genotype animals maintained a low cutaneous microflora, whilst hairless genotype animals gradually lost hair from head to tail and the microflora density increased. Reciprocal skin grafting between haired and hairless animals showed that the donor skin acquired the microflora characteristics of the recipient animal after 15 d post-grafting even though the donor skin remained morphologically true to genotype.
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