| First Author | Saunders AM | Year | 1990 |
| Journal | Genomics | Volume | 8 |
| Issue | 3 | Pages | 525-35 |
| PubMed ID | 1981054 | Mgi Jnum | J:10993 |
| Mgi Id | MGI:59435 | Doi | 10.1016/0888-7543(90)90040-2 |
| Citation | Saunders AM, et al. (1990) A molecular genetic linkage map of mouse chromosome 7. Genomics 8(3):525-35 |
| abstractText | The homology between mouse chromosome 7 and human chromosomes 11, 15, and 19 was examined using interspecific backcross animals derived from mating C3H/HeJ-gld/gld and Mus spretus mice. In an earlier study, we reported on the linkage relationships of 16 loci on mouse chromosome 7 and the homologous relationship between this chromosome and the myotonic dystrophy gene region on human chromosome 19. Segregation analyses were used to extend the gene linkage relationships on mouse chromosome 7 by an additional 21 loci. Seven of these genes (Cyp2a, D19F11S1h, Myod-1, Otf-2, Rnu1p70, Rnu2pa, and Xrcc-1) were previously unmapped in the mouse. Several potential mouse chromosome 7 genes (Mel, Hkr-1, Icam-1, Pvs) did not segregate with chromosome 7 markers, and provisional chromosomal assignments were made. This study establishes a detailed molecular genetic linkage map of mouse chromosome 7 that will be useful as a framework for determining linkage relationships of additional molecular markers and for identifying homologous disease genes in mice and humans. |
