First Author | Sikela JM | Year | 1990 |
Journal | Genomics | Volume | 8 |
Issue | 3 | Pages | 579-82 |
PubMed ID | 1981056 | Mgi Jnum | J:10997 |
Mgi Id | MGI:59439 | Doi | 10.1016/0888-7543(90)90048-y |
Citation | Sikela JM, et al. (1990) Genetic mapping of the gene for Ca2+/calmodulin-dependent protein kinase IV (Camk-4) to mouse chromosome 18. Genomics 8(3):579-82 |
abstractText | Southern blot analysis of Chinese hamster x mouse somatic cell hybrids was used to map the gene for a serine/threonine protein kinase expressed in brain and testis. This locus, termed Camk-4, encodes Ca2+/calmodulin-dependent protein kinase IV. Progeny of an interspecific backcross were analyzed to position Camk-4 in the centromeric region of chromosome 18 near two mutations known to affect neurological function and fertility. This raises the possibility that a defect in Camk-4 may be responsible for one of these mutant phenotypes. |