| First Author | Kaushik A | Year | 1991 |
| Journal | Eur J Immunol | Volume | 21 |
| Issue | 3 | Pages | 827-30 |
| PubMed ID | 1901267 | Mgi Jnum | J:11075 |
| Mgi Id | MGI:59517 | Doi | 10.1002/eji.1830210344 |
| Citation | Kaushik A, et al. (1991) Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice. Eur J Immunol 21(3):827-30 |
| abstractText | The contribution of VH11 gene family to the development of the primary B cell repertoire has been studied by analyzing 1.8 x 10(4) mitogen induced B lymphocyte colonies. The data demonstrate that VH11 family is predominantly expressed among neonatal splenic as well as adult peritoneal B cell colonies, both rich in Ly-1+ B cells. VH11 gene family expression among B splenocytes decreases during ontogeny and VH11 family pairs stochastically with different V kappa families among mitogen-activated neonatal B cell colonies, which are representative of an antigen unselected B cell repertoire. Thus, an increased VH11 expression among peritoneal and neonatal B cells points towards its biased expression among Ly-1+ B lymphocytes. The restricted V gene rearrangements and VH11-V kappa 9 pairing observed among anti-bromelain-treated mouse red blood cells autoantibodies are likely to be an outcome of both intrinsic gene recombination processes per se as well as selection by an autoantigen and/or local selective environmental factors. |
