| First Author | Grant SG | Year | 1991 |
| Journal | Oncogene | Volume | 6 |
| Issue | 3 | Pages | 397-402 |
| PubMed ID | 2011396 | Mgi Jnum | J:11094 |
| Mgi Id | MGI:59536 | Citation | Grant SG, et al. (1991) Detailed genetic mapping of the A-raf proto-oncogene on the mouse X chromosome. Oncogene 6(3):397-402 |
| abstractText | The transcribed murine A-raf proto-oncogene has been localized to the proximal region of the mouse X chromosome, within the context of four other active genes in this region which together constitute a conserved linkage group between mouse and man. This localization has been accomplished using species-specific restriction fragment length variation and DNAs from a previously defined informative subset of progeny representative of a set of 100 progeny from an interspecific backcross between inbred C57BL/6JRos and wild-derived Mus spretus. This new data regionally orders the mouse A-raf locus relative to the 24 X-linked markers previously examined in this backcross. We find that A-raf co-localizes with two other active genes, tissue inhibitor of metalloproteinases (Timp) and synapsin (Syn-1), 4.0 +/- 2.0 cM distal to the Otc gene at the proximal end of the mouse X chromosome, for a partial gene order in this region of: centromere-Cybb-Otc-Timp/A-raf/Syn-1-Xlr-1-Hprt. |
