| First Author | Tsutsui J | Year | 1991 |
| Journal | Biochem Biophys Res Commun | Volume | 176 |
| Issue | 2 | Pages | 792-7 |
| PubMed ID | 2025291 | Mgi Jnum | J:3607 |
| Mgi Id | MGI:52118 | Doi | 10.1016/s0006-291x(05)80255-4 |
| Citation | Tsutsui J, et al. (1991) A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse. Biochem Biophys Res Commun 176(2):792-7 |
| abstractText | A retinoic acid responsive gene, MK, specifies for a heparin binding factor termed midkine (MK), which is the initial member of a new protein family involved in regulation of growth and differentiation. A cDNA clone of human MK was isolated from a fetal kidney cDNA library. Human MK mRNA was expressed in PA1 teratocarcinoma cells as well as in the kidney. Sequence analysis of the cDNA clone and of a part of the genomic clone yielded the predicted protein sequence of human MK. Human and mouse MK sequences are highly conserved: 87% of amino acids are identical and all amino acid changes are conservative except for an insertion. Comparison of MK and HB-GAM/pleiotrophin (another member of the family) from various species revealed sequences conserved in the family and those specific for each protein. |
