| First Author | Borsani G | Year | 1991 |
| Journal | Nature | Volume | 351 |
| Issue | 6324 | Pages | 325-9 |
| PubMed ID | 2034278 | Mgi Jnum | J:11179 |
| Mgi Id | MGI:59621 | Doi | 10.1038/351325a0 |
| Citation | Borsani G, et al. (1991) Characterization of a murine gene expressed from the inactive X chromosome. Nature 351(6324):325-9 |
| abstractText | In mammals, equal dosage of gene products encoded by the X chromosome in male and female cells is achieved by X inactivation. Although X-chromosome inactivation represents the most extensive example known of long range cis gene regulation, the mechanism by which thousands of genes on only one of a pair of identical chromosomes are turned off is poorly understood. We have recently identified a human gene (XIST) exclusively expressed from the inactive X chromosome. Here we report the isolation and characterization of its murine homologue (Xist) which localizes to the mouse X inactivation centre region and is the first murine gene found to be expressed from the inactive X chromosome. Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation. |
