| First Author | Geurts van Kessel A | Year | 1991 |
| Journal | Hum Genet | Volume | 87 |
| Issue | 2 | Pages | 201-4 |
| PubMed ID | 1648546 | Mgi Jnum | J:11306 |
| Mgi Id | MGI:59745 | Doi | 10.1007/BF00204182 |
| Citation | Geurts van Kessel A, et al. (1991) Localization of the cellular retinoic acid binding protein (CRABP) gene relative to the acute promyelocytic leukemia-associated breakpoint on human chromosome 15. Hum Genet 87(2):201-4 |
| abstractText | A human genomic fragment comprising the cellular retinoic acid binding protein (CRABP) gene was isolated. By using a panel of somatic cell hybrids, this gene could be assigned to human chromosome 15. Subsequently, a possible involvement of the CRABP gene in translocation (15;17) (q22;q11) positive acute promyelocytic leukemia (APL) was investigated. Although transposition of the CRABP gene could be demonstrated, we did not observe any gross CRABP rearrangement in a series of primary APL patients, nor in the acute myeloblastic leukemia cell line HL-60. Thus, the observed lack of CRABP expression in these leukemic cells may not be caused by disruption of its gene. CRABP maps to the region 15q22-qter. |
