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Publication : Murine candidiasis: sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5.

First Author  Ashman RB Year  1991
Journal  Immunol Cell Biol Volume  69 ( Pt 1)
Pages  7-10 PubMed ID  1831181
Mgi Jnum  J:27574 Mgi Id  MGI:75063
Doi  10.1038/icb.1991.2 Citation  Ashman RB, et al. (1991) Murine candidiasis: sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5. Immunol Cell Biol 69(Pt 1):7-10
abstractText  Mice deficient in the fifth component of complement are known to be extremely susceptible to lethal challenge with Candida albicans. However, male mice, that have significantly higher concentrations of serum C5 than females, were markedly more susceptible to infection. This difference was observed in both susceptible (CBA/H) and resistant (BALB/c) mice. Levels of serum C3 likewise showed no correlation with susceptibility.
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