| First Author | Andujar MB | Year | 1991 |
| Journal | Development | Volume | 111 |
| Issue | 3 | Pages | 691-8 |
| PubMed ID | 1879336 | Mgi Jnum | J:32247 |
| Mgi Id | MGI:79728 | Doi | 10.1242/dev.111.3.691 |
| Citation | Andujar MB, et al. (1991) Differential expression of type I and type III collagen genes during tooth development. Development 111(3):691-8 |
| abstractText | Collagen gene expression during mouse molar tooth development was studied by quantitative in situ hybridization techniques. Different expression patterns of type I and type III collagen mRNAs were observed in the various mesenchymal tissues that constitute the tooth germ. High concentration for pro-alpha 1(I) and pro-alpha 2(I) collagen mRNAs were found within the osteoblasts. We found that the cellular content of type I collagen mRNAs in the odontoblasts varies throughout the tooth formation: whereas mRNA concentration for pro-alpha 1(I) collagen decreases and that of pro-alpha 2(I) increases, during postnatal development. Moreover, different amounts of pro-alpha 1(I) and pro-alpha 2(I) collagen mRNAs were observed in crown and root odontoblasts, respectively. Type III collagen mRNAs were detected in most of the mesenchymal cells, codistributed with type I collagen mRNAs, except in odontoblasts and osteoblasts. Finally, this study reports differential accumulation of collagen mRNAs during mouse tooth development and points out that type I collagen gene expression is regulated by distinct mechanisms during odontoblast differentiation process. These results support the independent expression of the collagen genes under developmental tissue-specific control. |
