| First Author | Badiani A | Year | 1991 |
| Journal | Psychopharmacology (Berl) | Volume | 104 |
| Issue | 1 | Pages | 57-61 |
| PubMed ID | 1882004 | Mgi Jnum | J:27672 |
| Mgi Id | MGI:75161 | Doi | 10.1007/BF02244554 |
| Citation | Badiani A, et al. (1991) Reduction of oxotremorine-induced analgesia after chronic but not acute restraint stress. Psychopharmacology (Berl) 104(1):57-61 |
| abstractText | The analgesic response (tail-flick latency) induced by the muscarinic cholinergic agonist oxotremorine was investigated in DBA/2 mice exposed to acute (a single 2 h session) and chronic (2 h once daily for 10 days) restraint stress. While a single exposure to stress did not influence the antinociceptive effects of the cholinergic agonist, chronic stress induced a clear-cut reduction of the oxotremorine-induced analgesia. The results show an involvement of cholinergic mechanisms in the adaptive modulation of nociception after chronic stressful events. |
