| First Author | Hilliker CE | Year | 1991 |
| Journal | Genomics | Volume | 10 |
| Issue | 4 | Pages | 867-73 |
| PubMed ID | 1655632 | Mgi Jnum | J:375 |
| Mgi Id | MGI:48913 | Doi | 10.1016/0888-7543(91)90174-d |
| Citation | Hilliker CE, et al. (1991) Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. Genomics 10(4):867-73 |
| abstractText | Two genes encoding 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase were localized in human and rat chromosomes. PFKFB1 (previously PFRX), which encodes the liver and muscle isozymes, was assigned to Xq22-q31 in the rat and to Xq27-q28 in the human by in situ hybridization using probes generated by the polymerase chain reaction. PFKFB2, which encodes the heart isozyme of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, was assigned to chromosome 13 in the rat and to chromosome 1 in the human by hybridization of DNA from somatic cell hybrids. By in situ hybridization, this gene was localized to the regions 13q24-25 in the rat and 1q31 in the human. |
