| First Author | van Zutphen LF | Year | 1991 |
| Journal | Lab Anim | Volume | 25 |
| Issue | 3 | Pages | 193-7 |
| PubMed ID | 1921313 | Mgi Jnum | J:11506 |
| Mgi Id | MGI:59936 | Doi | 10.1258/002367791780808329 |
| Citation | van Zutphen LF, et al. (1991) Segregation of genes from donor strain during the production of recombinant congenic strains. Lab Anim 25(3):193-7 |
| abstractText | Recombinant congenic strains (RCS) constitute a set of inbred strains which are designed to dissect the genetic control of multigenic traits, such as tumour susceptibility or disease resistance. Each RCS contains a small fraction of the genome of a common donor strain, while the majority of genes stem from a common background strain. We tested at two stages of the inbreeding process in 20 RCS, derived from BALB/cHeA and STS/A, to see whether alleles from the STS/A donor strain are distributed over the RCS in a ratio as would theoretically be expected. Four marker genes (Pep-3; Pgm-1; Gpi-1 and Es-3) located at 4 different chromosomes were selected and the allelic distribution was tested after 3-4 and after 12 generations of inbreeding. The data obtained do not significantly deviate from the expected pattern, thus supporting the validity of the concept of RCS. |
