| First Author | Messiha FS | Year | 1991 |
| Journal | Comp Biochem Physiol C | Volume | 99 |
| Issue | 3 | Pages | 323-6 |
| PubMed ID | 1723037 | Mgi Jnum | J:4052 |
| Mgi Id | MGI:52553 | Doi | 10.1016/0742-8413(91)90249-s |
| Citation | Messiha FS (1991) Genotype-treatment interaction between amantadine and chlorpromazine in the mouse. Comp Biochem Physiol C 99(3):323-6 |
| abstractText | 1. Repeated administration of amantadine prior to chlorpromazine to two different strains of mice altered both locomotor activity, concentrations of brain biogenic amines and selected major metabolites as a function of mouse strain. 2. Amantadine antagonized chlorpromazine effect on motility which was associated with increases in whole brain levels of homovanillic acid in the CDF-1 but not C57BL/6 mice. 3. Conversely, the treatment with amantadine prior to chlorpromazine reduced whole brain normetanephrine and 5-hydroxyindoleacetic acid levels from respective controls in the C57BL/6 and CDF-1 mice, respectively. 4. The results suggest that genetic factors underly differential alteration of brain dopamine and serotonin which may underly the mechanism of amantadine efficacy in neuroleptic-induced extrapyramidal disorders and to the variable responses to amantadine therapy. |
