| First Author | Sakaguchi AY | Year | 1992 |
| Journal | Genomics | Volume | 12 |
| Issue | 1 | Pages | 151-4 |
| PubMed ID | 1733852 | Mgi Jnum | J:1926 |
| Mgi Id | MGI:50450 | Doi | 10.1016/0888-7543(92)90418-r |
| Citation | Sakaguchi AY, et al. (1992) Assignment of tyrosine-specific T-cell phosphatase to conserved syntenic groups on human chromosome 18 and mouse chromosome 18. Genomics 12(1):151-4 |
| abstractText | Phosphorylation of proteins on tyrosine is crucially involved in signal transduction and mitogenesis and is regulated by both kinases and phosphatases. Recently, a number of soluble and transmembrane receptor-linked protein tyrosine phosphatases (PTPase) have been characterized. Among these is a 48.4-kDa PTPase encoded by a cDNA isolated from a T-lymphocyte library by low-stringency screening with probes derived from placental PTPase 1B. A human T-cell PTPase (PTPT) cDNA and somatic cell hybrids were used to assign a PTPT gene to conserved syntentic groups on human chromosome 18 and on mouse chromosome 18. Two unlinked sequences, one on human chromosome 1, were also detected. |
