| First Author | Kataoka Y | Year | 1991 |
| Journal | J Vet Med Sci | Volume | 53 |
| Issue | 6 | Pages | 1043-9 |
| PubMed ID | 1790214 | Mgi Jnum | J:27889 |
| Mgi Id | MGI:75524 | Doi | 10.1292/jvms.53.1043 |
| Citation | Kataoka Y, et al. (1991) Experimental infections of mice and pigs with Streptococcus suis type 2. J Vet Med Sci 53(6):1043-9 |
| abstractText | Five inbred strains of mice were tested for their susceptibility to Streptococcus suis type 2 including the type strain, two isolates from meningitis in pigs and two isolates from tonsils of clinically healthy pigs. C57BL/6, ICR and ddY strain mice showed lower susceptibility to all strains of S. suis type 2 than BALB/c and SS strain mice. The type strain and the isolates from diseased pigs produced septicaemia and meningitis in BALB/c and SS mice inoculated with 10(8) colony forming unit of the bacteria and 60 to 100% of these infected mice died. On the other hand, mice inoculated with the isolates from healthy pigs showed mild clinical signs but none of them died. In BALB/c mice which died or developed nervous signs, the purulent meningo-encephalitis, myocarditis, ophthalmitis, labyrinthitis and otitis media were observed. S. suis type 2 antigen was demonstrated in these lesions by immunoperoxidase staining using rabbit S. suis type 2 antiserum. These results were similar to those in the experimentally infected pigs with these virulent and avirulent strains against mice. These results indicate that BALB/c and SS strains of mice are useful as an experimental model of S. suis type 2 infections in pigs, and that there are virulent and avirulent strains against mice and pigs among the strains of S. suis type 2. |
