| First Author | McDonald TP | Year | 1992 |
| Journal | Proc Soc Exp Biol Med | Volume | 199 |
| Issue | 3 | Pages | 287-90 |
| PubMed ID | 1539031 | Mgi Jnum | J:2757 |
| Mgi Id | MGI:51279 | Doi | 10.3181/00379727-199-43358 |
| Citation | McDonald TP, et al. (1992) Effects of hypoxia on megakaryocyte size and number of C3H and BALB/c mice. Proc Soc Exp Biol Med 199(3):287-90 |
| abstractText | In an effort to explain the different platelet production capabilities of both normal and hypoxic male and female C3H and BALB/c mice, megakaryocyte size and number were determined utilizing bone marrow from both normal and hypoxic mice. The results indicate that normal BALB/c female mice have increased numbers of megakaryocytes, but of smaller size compared with either BALB/c male mice or to both sexes of C3H mice. An inverse relationship between the size and number of megakaryocytes was found in both normal and hypoxic mice; therefore, to evaluate total megakaryocyte characteristics, we calculated total megakaryocyte masses (TMM). With hypoxia, megakaryocyte number decreased, whereas megakaryocyte size increased. Despite the increase in megakaryocyte size, hypoxia caused a significant decrease in TMM (P less than 0.005) in all mice, but female C3H mice had higher TMM (P less than 0.05) than did female BALB/c mice. These data show that hypoxia decreases TMM in mice, and that the effect is greater in C3H mice than in BALB/c mice. |
