| First Author | Soares LR | Year | 1992 |
| Journal | J Leukoc Biol | Volume | 51 |
| Issue | 3 | Pages | 220-4 |
| PubMed ID | 1541906 | Mgi Jnum | J:4648 |
| Mgi Id | MGI:53132 | Doi | 10.1002/jlb.51.3.220 |
| Citation | Soares LR, et al. (1992) Differential production of granulocyte-macrophage colony-stimulating factor by macrophages from mice susceptible and resistant to Leishmania mexicana amazonensis. J Leukoc Biol 51(3):220-4 |
| abstractText | The present results demonstrate that macrophages from mice susceptible to infection with Leishmania mexicana amazonensis sustain a higher production of granulocyte-macrophage colony-stimulating factor (GM-CSF) throughout the in vitro infection than macrophages from a resistant strain. Resident macrophages from BALB/c and C57B1/10 mice were infected with promastigotes of L. mexicana amazonensis and the amount of biologically active GM-CSF was measured in the supernatants collected at different times of infection. Measurements were made by bone marrow and GM-CSF/interleukin-3 addicted cell proliferation. Because GM-CSF is a disease-exacerbating cytokine, its differential production by infected macrophages may be one of the mechanisms defining resistance or susceptibility to a leishmanial infection. |
