| First Author | Gearing DP | Year | 1992 |
| Journal | Science | Volume | 255 |
| Issue | 5050 | Pages | 1434-7 |
| PubMed ID | 1542794 | Mgi Jnum | J:35072 |
| Mgi Id | MGI:82526 | Doi | 10.1126/science.1542794 |
| Citation | Gearing DP, et al. (1992) The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science 255(5050):1434-7 |
| abstractText | Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are multifunctional cytokines with many similar activities. LIF is structurally and functionally related to another cytokine, Oncostatin M (OSM), that binds to the high-affinity LIF receptor but not to the low-affinity LIF receptor. A complementary DNA was isolated that encodes the high-affinity converting subunit of the LIF receptor. The converter conferred high-affinity binding of both LIF and OSM when expressed with the low-affinity LIF receptor and is identical to the signal transducing subunit of the IL-6 receptor, gp130. The gp130 subunit alone confers low-affinity binding of OSM when expressed in COS-7 cells. This receptor system resembles the high-affinity receptors for granulocyte-macrophage colony-stimulating factor, IL-3, and IL-5, which share a common subunit. |
