| First Author | Danciger M | Year | 1992 |
| Journal | Genomics | Volume | 12 |
| Issue | 4 | Pages | 688-92 |
| PubMed ID | 1572642 | Mgi Jnum | J:2303 |
| Mgi Id | MGI:50827 | Doi | 10.1016/0888-7543(92)90295-4 |
| Citation | Danciger M, et al. (1992) Localization of the gene for a third G protein beta-subunit to mouse chromosome 6 near Raf-1. Genomics 12(4):688-92 |
| abstractText | The large family of signal transducing proteins known as G proteins are heterotrimers that dissociate into an independent alpha-subunit and beta gamma-subunit complex after ligand binding or other stimulation. For G alpha, at least 30 distinct sequences representing 10 different classes have been identified. On the other hand, cDNAs for only three G beta-subunit genes have been isolated so far. All three of the G beta genes have been chromosomally mapped in the human, but only two in the mouse. Using a human retinal cDNA for the third G protein beta-subunit, we have mapped the corresponding gene, termed Gnb-3, to mouse Chromosome 6 with somatic cell hybrids and have positioned it distal to but near the marker Raf-1 by analysis of the progeny of three genetic crosses. |
