| First Author | Laval SH | Year | 1992 |
| Journal | Genomics | Volume | 12 |
| Issue | 4 | Pages | 818-21 |
| PubMed ID | 1572655 | Mgi Jnum | J:1611 |
| Mgi Id | MGI:50138 | Doi | 10.1016/0888-7543(92)90315-j |
| Citation | Laval SH, et al. (1992) Mapping of FMR1, the gene implicated in fragile X-linked mental retardation, on the mouse X chromosome. Genomics 12(4):818-21 |
| abstractText | A genetic map of the Cf-9 to Dmd region of the mouse X chromosome has been established by typing 100 offspring from a Mus musculus x Mus spretus interspecific backcross for the four loci Cf-9, Cdr, Gabra3, and Dmd. The following order and genetic distances in centimorgans were determined: (Cf-9)-2.4 +/- 1.7-(Cdr)-2.0 +/- 1.4-(Gabra3)-4.1 +/- 2.0-(Dmd). Six backcross offspring carrying X chromosomes with recombination events in the Cdr-Dmd region were identified. These recombination events were used to define the position of Fmr-1, the murine homologue of FMR1, which is the gene implicated in the fragile X syndrome in man, and that of DXS296h, the murine homologue of DXS296. Both Fmr-1 and DXS296h were mapped into the same recombination interval as Gabra3 on the mouse X chromosome. These findings provide strong support for the concept that the order of loci lying in the Cf-9 to Gabra3 segment of the X chromosome is highly conserved between human and mouse. |
