| First Author | Arceci RJ | Year | 1992 |
| Journal | Dev Biol | Volume | 151 |
| Issue | 1 | Pages | 1-8 |
| PubMed ID | 1374350 | Mgi Jnum | J:757 |
| Mgi Id | MGI:49291 | Doi | 10.1016/0012-1606(92)90207-w |
| Citation | Arceci RJ, et al. (1992) Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse development. Dev Biol 151(1):1-8 |
| abstractText | c-fms and c-kit are structurally related tyrosine kinase receptors for colony-stimulating factor-1 (CSF-1) and for steel factor (SF), respectively. The level of c-fms mRNA, like c-kit mRNA, increases during the maturation of oocytes and is an abundant maternal message found in the unfertilized oocyte. Following fertilization, the level of both c-fms and c-kit oocyte mRNAs decreases rapidly until they are no longer detected by the early 2-cell stage. By the late 2-cell stage, both mRNAs are reexpressed, albeit at low levels. This low level of mRNA expression continues throughout preimplantation development. CSF-1 and SF transcripts are not detected in early preimplantation embryos, but are detected in cumulus cells, oviduct, and uterus, suggesting a paracrine action of these growth factors during the preimplantation period. The patterns of CSF-1/c-fms mRNA and SF/c-kit mRNA expression are consistent with the hypothesis that these two ligand/receptor systems may act in a compensatory or synergistic manner during preimplantation development. |
