| First Author | Brown KA | Year | 1992 |
| Journal | Genomics | Volume | 13 |
| Issue | 1 | Pages | 189-93 |
| PubMed ID | 1349573 | Mgi Jnum | J:470 |
| Mgi Id | MGI:49007 | Doi | 10.1016/0888-7543(92)90219-i |
| Citation | Brown KA, et al. (1992) Close linkage of the olfactory marker protein gene to the mouse deafness mutation shaker-1. Genomics 13(1):189-93 |
| abstractText | One thousand sixty-six progeny have been generated from a backcross segregating for the mouse deafness mutation, shaker-1 (sh-1). One thousand fifty-two mice were analyzed for a protein polymorphism segregating for the distal flanking marker, beta-globin (Hbb), and 13 recombinants between Hbb and sh-1 were identified. One thousand eight mice were analyzed for a restriction fragment length polymorphism segregating for the proximal flanking marker, tyrosinase (c), and 54 recombinants between c and sh-1 were identified, completing a panel of 67 recombinant mice from the backcross in the vicinity of the sh-1 mutation. This panel allows the identification of markers closely linked to the sh-1 mutation that may act as start points for a chromosomal walk to the gene. One such marker, the olfactory marker protein gene (Omp), is recombinant with sh-1 in only one mouse from the recombinant panel. Thus, the Omp gene lies 0.1 cM from sh-1, on average, a distance of 200 kb. Haplotype analysis indicates that Omp lies proximal to sh-1. |
