| First Author | Teuber SS | Year | 1991 |
| Journal | J Autoimmun | Volume | 4 |
| Issue | 6 | Pages | 857-70 |
| PubMed ID | 1667467 | Mgi Jnum | J:693 |
| Mgi Id | MGI:49227 | Doi | 10.1016/0896-8411(91)90049-i |
| Citation | Teuber SS, et al. (1991) The identification and cloning of the murine genes encoding the liver specific F alloantigens. J Autoimmun 4(6):857-70 |
| abstractText | The liver specific F alloantigen is a highly conserved abundant protein found in hepatic cytoplasm; smaller amounts are detected in renal tubule cells and the perikaryon cells of the central nervous system. Although the biological function of the F alloantigen is unknown, the immune response to F has been extensively studied as a murine model of tolerance and autoimmunity. Murine F exists in two allelic forms, designated F type 1 and type 2, each of approximately 43 kDa. The immune response to the allotypic form is restricted to mouse strains of I-Ak. Responding strains immunized with allotypic F break tolerance and produce precipitating antibody that reacts with both allelic forms, i.e., immunogen and self. Thus an autoantibody is produced. Using the previously isolated rat F cDNA as a probe, we report the cloning and sequencing of the two murine F allotypes. These two alleles are nearly homologous except at the extremes of the coding sequence. There are a number of regions within the F sequence that are similar to peptides that interact specifically with I-Ak. In particular, there is a sequence near the carboxy terminus, where the two allotypes differ, that has homology to the I-Ak restricted malarial antigen peptide of the ring-infected erythrocyte surface antigen (RESA). |
