| First Author | Hall JM | Year | 1992 |
| Journal | Am J Hum Genet | Volume | 50 |
| Issue | 6 | Pages | 1235-42 |
| PubMed ID | 1598904 | Mgi Jnum | J:1101 |
| Mgi Id | MGI:49633 | Citation | Hall JM, et al. (1992) Closing in on a breast cancer gene on chromosome 17q. Am J Hum Genet 50(6):1235-42 |
| abstractText | Linkage of early-onset familial breast and ovarian cancer to 11 markers on chromosome 17q12-q21 defines an 8-cM region which is very likely to include the disease gene BRCA 1. The most closely linked marker is D17S579, a highly informative CA repeat polymorphism. D17S579 has no recombinants with inherited breast or ovarian cancer in 79 informative meioses in the seven families with early-onset disease (lod score 9.12 at zero recombination). There is no evidence for linkage heterogeneity in the families with early-onset disease. The proportion of older-onset breast cancer attributable to BRCA 1 is not yet determinable, because both inherited and sporadic cases occur in older-onset families. |
