| First Author | Graves PE | Year | 1992 |
| Journal | Biochem Biophys Res Commun | Volume | 185 |
| Issue | 1 | Pages | 310-6 |
| PubMed ID | 1599466 | Mgi Jnum | J:1074 |
| Mgi Id | MGI:49606 | Doi | 10.1016/s0006-291x(05)90001-6 |
| Citation | Graves PE, et al. (1992) An amino acid change in the DNA-binding region of Sry, found in Mus musculus domesticus and other species, does not explain C57BL/6J-YDOM sex-reversal. Biochem Biophys Res Commun 185(1):310-6 |
| abstractText | Sry is the testes determining factor gene located on the Y chromosome. We have performed dideoxy sequencing or restriction enzyme digestion of Sry sequences amplified by PCR from a variety of inbred strains and species of mice. A nonconservative replacement of Thr for Isoleu at position 61 was found in Sry from the Y chromosome of Mus musculus domesticus, Mus spretus, and Mus caroli. We demonstrate that this variation is not sufficient to explain the gradiation in the sex-reversal seen when different domesticus strains are bred to C57BL/6J females. |
