| First Author | Sherr CJ | Year | 1991 |
| Journal | Trends Genet | Volume | 7 |
| Issue | 11-12 | Pages | 398-402 |
| PubMed ID | 1840317 | Mgi Jnum | J:1748 |
| Mgi Id | MGI:50274 | Doi | 10.1016/0168-9525(91)90263-p |
| Citation | Sherr CJ (1991) Mitogenic response to colony-stimulating factor 1. Trends Genet 7(11-12):398-402 |
| abstractText | The proliferative effects of colony-stimulating factor 1 (CSF-1) on cells of the mononuclear phagocyte lineage are mediated by the CSF-1 receptor tyrosine kinase, which triggers intracellular signal transduction through multiple second messenger pathways. CSF-1 is required throughout G1 to stimulate both immediate- and delayed-early responses that ensure entry of macrophages into S phase. Because CSF-1 induces the expression of different sets of cellular genes during early and late G1, products of the immediate-early response might modulate the effects of ensuing receptor signals to facilitate G1 progression. Targets of the delayed-early response include novel cyclin genes that may play a role in S phase commitment. |
